- Release date: July 10, 2012
- Cover athletes: Robert Griffin III QB Baylor Bears, Barry Sanders RB Oklahoma State Cowboys (PS3, Xbox 360)
- The top 25 rankings are based on the default team rankings by EA Sports.
- Massachusetts, Texas State, and UTSA were added to the game this year. South Alabama also joined the FBS this year, but was mistakenly left out of the game.
- 99 Overall Club: None
- This was the first installment of the game to include past NCAA Heisman legends as playable characters. RB Marcus Allen, QB Doug Flutie, RB Eddie George, QB Robert Griffin III, WR Desmond Howard, QB Carson Palmer, RB Barry Sanders, QB Charlie Ward, QB Andre Ware, RB Herschel Walker are available to play as in the game. WR Tim Brown, RB Archie Griffin, and QB Jim Plunkett are available in the demo download and QB Mark Ingram, QB Matt Leinart, and QB Tim Tebow are available from a GameStop pre-order.
- Casey Pachall (Texas Christian Horned Frogs QB #4) was suspended from the team indefinitely shortly after the season began.
- Ryan Katz, former Oregon State QB, transferred to play for San Diego State, however he was left out of the game.
- Silas Redd (Penn State Nittany Lions HB #25) remains on Penn State's roster, however he transferred to play for Southern California.
- Tyrann Mathieu (Louisiana State Tigers CB #7) remains on LSU's roster, however he was dismissed from the team right before the season started.
Big East Rosters
Big Ten Rosters
Big 12 Rosters
Mountain West Rosters
Sun Belt Rosters
---> Source: Madden Ratings
---> Info: Personally created spreadsheet that shows the overall ratings and depth chart for every QB in the game.
---> Source: Goalkeepr (Operation Sports)
---> Info: Full detailed list of player ratings for every player in the game based on their class year. Players not named however.
---> Source: Compughter Ratings
---> Info: List of team ratings, player equipment, and team playbooks in the game.
---> Source: Tradition Sports Online
---> Info: List of every team's ratings and prestige in the game.
---> Source: Madden Ratings
---> Info: Personally created spreadsheet that has ever player in the game with an 88+ overall rating and has them named.
Top 25 Team Rankings
1. Alabama Crimson Tide
2. Southern California Trojans
3. Louisiana State Tigers
4. Oregon Ducks
5. Oklahoma Sooners
6. Georgia Bulldogs
7. Arkansas Razorbacks
8. Florida State Seminoles
9. Michigan Wolverines
10. West Virginia Mountaineers
11. South Carolina Gamecocks
12. Michigan State Spartans
13. Kansas State Wildcats
14. Clemson Tigers
15. Virginia Tech Hokies
16. Wisconsin Badgers
17. Texas Christian Horned Frogs
18. Ohio State Buckeyes
19. Nebraska Cornhuskers
20. Stanford Cardinal
21. Boise State Broncos
22. Texas Longhorns
23. Oklahoma State Cowboys
24. Notre Dame Fighting Irish
25. Florida Gators