- Release date: January 19th, 2018
- Cover athlete: N/A (PS4, Xbox One, Windows PC, Steam)
- The game features 18 teams, in 2 conferences, each having 3 divisions.
- On February 1st, 2018 the game announced it would add a 19th team, the Killadelphia Evils, to the game, since the Philadelphia Eagles are playing in the Super Bowl. The team can be added on in an update.
- On October 30th, 2018 the MFL added 4 team teams which can be purchased as downloadable content. They are the Karcass City Creeps, New Goreleans Zombies, Cracksumskull Jugulars, and Full Metal Mayhem.
- On October 30th, 2018 the MFL released a Dynasty Edition version of the game which includes 25 total teams including the new Purple Mutant Eaters and Hexxon Oilers.