Game Notes
- Release date: September 10, 2021
- Cover athletes: Luka Doncic SG Dallas Mavericks, Kevin Durant SF Brooklyn Nets, Dirk Nowitzki PF Dallas Mavericks, Candace Parker PF Chicago Sky (PS4, PS5, Xbox One X, Xbox One, Nintendo Switch, Windows PC)
Player Notes
- NOTABLE PLAYERS NOT IN THE GAME: Charles Barkley, Reggie Miller, Pau Gasol, Brandon Roy, Tyson Chandler, Lance Stephenson, Jamal Crawford, J.R. Smith, J.J. Barea, Drazen Petrovic, Marco Belinelli, Kyle Korver, Thabo Sefolosha, Nene, J.J. Barea, Corey Brewer, Ian Mahinmi, Jamal Crawford
- New Players Added To The Game: Etan Thomas, Fred Hetzel ,Kurt Thomas, Ronnie Brewer, Rudy Fernandez, Winston Bennett, Juwan Howard, Mike Gminski, Randy Brown, Matt Bonner, Brian Cook, Speedy Claxton, Mike Penberthy, Kevin Grevey, Willie Burton, Lawrence Funderburke
- No new classic rosters were added to the game.