- Release date: August 25, 2017 (Based on the 2017 NFL season.)
- Cover athlete: Tom Brady QB New England Patriots (PS4, Xbox One)
- The San Diego Chargers relocated to become the Los Angeles Chargers.
- The Oakland Raiders announced they would relocate and become the Las Vegas Raiders, but not until the 2019 or 2020 season.
- 99 Overall Club: QB Tom Brady (Patriots), RE Aaron Donald (Rams), LOLB Von Miller (Broncos)
- Miami Dolphins sign Retired Free Agent QB Jay Cutler (78 OVR) in the Launch Roster Update.