- Release date: September 12, 2001 (Based on on the 2001 NFL season.)
- Cover athlete: Daunte Culpepper QB Minnesota Vikings (Game Boy Advance, Game Boy Color, GameCube, Nintendo DS, PlayStation, PS2, Xbox, Windows PC)
- This is the first Madden to feature the Houston Texans in the team select. The new expansion franchise is also available to play in the Franchise mode, in it's second year.
- 99 Overall Club: RB Marshall Faulk (Rams), TE Tony Gonzalez (Chiefs), LT Jonathan Ogden (Ravens), DT Warren Sapp (Buccaneers), MLB Ray Lewis (Ravens)