- Release date: August 14, 2009 (Based on the 2009 NFL season.)
- Cover athletes: Troy Polamalu SS Pittsburgh Steelers, Larry Fitzgerald WR Arizona Cardinals (PS2, PS3, PSP, Wii, Xbox 360, iOS)
- This is the first game in the series with a new player ratings philosophy, in which the ratings have been re-scaled for a more noticeable difference between players.
- 99 Overall Club: QB Peyton Manning (Colts), WR Larry Fitzgerald (Cardinals), DT Albert Haynesworth (Redskins), FS Ed Reed (Ravens), SS Troy Polamalu (Steelers), CB Nnamdi Asomugha (Raiders)
- Minnesota Vikings sign QB Brett Favre (82 OVR) in Roster Update #2.
- Philadelphia Eagles sign QB Michael Vick (73 OVR) in Roster Update #2.