- 99 Overall Club: QB Peyton Manning (Colts), QB Tom Brady (Patriots), RB LaDainian Tomlinson (Chargers), TE Antonio Gates (Chargers), WR Randy Moss (Patriots), SS Bob Sanders (Colts)
- In the default version of the game QB Brett Favre is on the "NFL Greats" roster. To make him a playable player with a team, you must release him from the "NFL Greats" roster and sign him to another team.
- Free Agent QB Brett Favre signed with the New York Jets in Roster Update #1.
- New York Jets QB Chad Pennington signed with the Miami Dolphins in Roster Update #2.
- Pittsburgh Steelers sign QB Byron Leftwich in Roster Update #2.
- Detroit Lions sign QB Daunte Culpepper in Roster Update #10.