- Release date: August 22, 2006 (Based on the 2006 NFL season.)
- Cover athlete: Shaun Alexander RB Seattle Seahawks, John Madden HC Oakland Raiders (GameCube, Nintendo DS, PS2, PS3, PSP, Wii, Xbox, Xbox 360, Mac OS X, Windows PC, Game Boy Advance)
- 99 Overall Club: QB Peyton Manning (Colts), FB Lorenzo Neal (Chargers), TE Antonio Gates (Chargers), LT Walter Jones (Seahawks), FS Ed Reed (Ravens), CB Champ Bailey (Broncos), P Shane Lechler (Raiders)
- Free Agent QB Enson Chaudoir (59 OVR) is listed in the game, but is a fictional character. He is said to resemble rookie QB Matt Baker from North Carolina.